SUBCUTANEOUS PANNICULITIS‐LIKE T‐CELL LYMPHOMA: MOLECULAR AND MUTATIONAL CHARACTERIZATION COMPARED WITH LUPUS PANNICULITIS AND HISTOPATHOLOGIC OVERLAPPING CASES

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare cytotoxic primary cutaneous whose histopathologic differential diagnosis with lupus erythematosus panniculitis (LEP) can be challenging, and overlapping cases have been described. In this study we investigate whether gene expression profiling using customized NanoString platform may identify markers that used to improve our understanding of the disease make more precise diagnosis. Twenty-two SPTCL, LEP were analyzed includes 208 genes related differentiation, stromal signatures, oncogenes tumor suppressor genes. Unsupervised analysis samples identified three clusters differentiated SPTCL from samples. Most (4/5) clustered cases, only one case was grouped cases. We 60 30 respectively upregulated downregulated in compared LEP. Differentially expressed observed when comparing Gene set enrichment recognized sets defining each group. mutations epigenetic modificatory ARID1A, EZH2, TET2, DNMT3A, NCOR1; TP53, PLCG1 four out six analyzed. Only showed HAVCR2 mutation. conclusion, distinctive molecular profiles. The background closely resembles than it does SPTCL. research funded by: Instituto de Salud Carlos III, Ministry Science Innovation Spain, PI17/2172. Keywords: Diagnostic Prognostic Biomarkers, Cutaneous non-Hodgkin No conflicts interest pertinent abstract.